Ultracentrifuges & Systems

Guide-Rail Controlled Piercing: Utilizes a rigid slide rail system that guides needle movements along a fixed vector, facilitating hands-free puncturing and mitigating accidental needle sticks or sharps hazards.

Secure Tube Holders: Features heavy-duty, stable positioning mounts that lock various centrifuge tubes firmly in place, eliminating tube slippage, preventing spills, and minimizing fluid agitation.

Dimmable LED Illumination: Equipped with an integrated, adjustable LED back-light system that illuminates the sample tube directly, allowing operators to clearly visualize and target fraction bands without lifting or shifting the tube.

Precision Graduations: Incorporates clear, highly visible measurement markings along the assembly to facilitate repeatable, accurate needle positioning across identical runs.

Sterility Optimization: Designed to support a sterile workflow, featuring a single-use sterile syringe adapter mechanism optimized for cleanroom and biosafety cabinet integration.

Precision Viral Band Recovery: Standardized needle positioning for harvesting high-purity fractions of Adeno-Associated Virus (AAV), Lentivirus, and Adenovirus directly from gradient matrices.

Exosome Fraction Extraction: Controlled collection of distinct extracellular vesicle (EV) and exosome subpopulations without disturbing adjacent, non-target density layers.

Iso-Density Gradient Harvesting: Mechanical recovery of target biological materials from density media arrays, including continuous or step gradients composed of Cesium Chloride (CsCl), Sucrose, or Iodixanol.

Subcellular Organelle Isolation: Clean extraction of isolated cellular components, such as intact mitochondria, nuclei, or microsomal layers, following differential centrifugation.

Automated Gradient Preparation: Automates the formation of complex linear and step density gradients, removing the need for manual layered pipetting or gravity-driven gradient makers.

Integrated Tube Sealing: Incorporates automated tube sealing directly into the dispense program, minimizing operator exposure to sharps or hazardous biological materials and standardizing containment for Quick-Seal configurations.

Run Time Optimization: By generating pre-formed linear gradients prior to centrifugation, the system eliminates the extended run hours typically required for a density gradient to form under centrifugal force. This enables separation protocols to rely strictly on particle migration, cutting subsequent centrifuge separation times by over 75%.

Protocol Standardization: Features an intuitive user interface that allows operators to easily create, specify, and publish custom methods detailing specific tube formats, reagents, and gradient volumes.

Setup Verification: Employs a step-by-step graphical workflow guide to walk users through labware loading, accessory connection, and fluidic line placement, ensuring fast operator training and minimized setup errors.

Advanced Downstream Viral Vector Purification: Rapid preparation of precision gradients for separating full vs. empty capsids in Adeno-Associated Virus (AAV), Adenovirus (AdV), and virus-like particles (VLPs) workflows.

Extracellular Vesicle & Exosome Isolation: Generation of continuous or step density matrices (such as Iodixanol or Sucrose) to fractionate delicate exosome subpopulations and extracellular vesicles (EVs) based on specific buoyant density.

Density Reagent Compatibility: Automated dispensing and mixing protocols validated for major density gradient media including Sucrose, Cesium Chloride (CsCl), and Iodixanol solutions.

Subcellular and Macromolecular Fractionation: High-reproducibility sample preparation for isolating cell organelles, ribosomes/polysomes, proteins/protein complexes, and nucleic acids/plasmids.

Advanced Nano-Delivery Isolation: Size-distribution and density-based fractionation of lipid nanoparticles (LNPs), lipoproteins, and synthetic nanoparticles (NPs).