Centrifuges
Thermo Scientific™ M Series Microcentrifuges
Models included: MT17 / MT17R (Standard Speed) | MT21 / MT21R (High Speed)
Designed to support the pace and precision of modern laboratories, the Thermo Scientific M Series microcentrifuges deliver powerful micro-volume performance in a compact footprint. Delivering speeds up to 21,100 x g (MT21) or 17,000 x g (MT17), the M Series accommodates versatile tube capacities from standard 1.5/2.0 mL microcentrifuge tubes and 0.2 mL PCR strips to 5 mL and 10 mL tubes. Fitting easily into clinical diagnostic, molecular biology, and life science workflows, it stands out for its operational reliability, safety, and ease of use. Featuring versatile rotor configurations, rapid acceleration and deceleration, and eco-friendly GreenCool refrigeration technology in refrigerated models, it streamlines daily sample processing.
Technological Innovations & Core Capabilities
- Two Speed Performance Tiers: Select between 17,000 x g (MT17 Series) for routine micro-volume separations and up to 21,100 x g (MT21 Series) for demanding molecular protocols.
- High-Capacity & Versatile Rotor Options: Choose from seven optional rotors accommodating 1.5/2.0 mL microcentrifuge tubes, 0.2 mL PCR strips, 5 mL and 10 mL tubes or vessels, or specialized hematocrit capillaries.
- Dual-Row Rotor Efficiency: Innovative dual-row rotor options (24 x 1.5/2.0 mL + 18 x 0.2/0.5 mL) eliminate the need for tube adapters altogether during micro-volume processing.
- Eco-Friendly GreenCool™ Technology: Refrigerated models feature a next-generation natural refrigerant cooling system for enhanced sustainability and rapid thermal recovery.
- Ergonomic & Intuitive Control: Fast one-click™ centrifuge lid closure, easy-to-read displays, and intuitive controls simplify daily operations.
- Lightweight Polymer Rotors: Lightweight engineered polymer rotors deliver outstanding corrosion resistance, complemented by ergonomic one-click™ rotor opening and closing.
- Enhanced Operational Safety: Transparent rotor design enhances safety, supported by certified Thermo Scientific ClickSeal™ biocontainment lids.
- Regulatory Certifications: Available in IVD / IVD-MD models approved for use in clinical diagnostic applications, as well as General Use configurations.
Intended Applications
- Molecular Biology & Genomics: High-speed DNA/RNA extraction, spin-column nucleic acid isolation, and high-throughput PCR strip processing at up to 21,100 x g.
- Clinical Diagnostics & Pathology: Processing of micro-volume blood collection tubes, 5 mL / 10 mL analytical tubes or vessels, serum/plasma separation, and specialized hematocrit determination under IVD compliance.
- Biochemistry & Cell Biology: Protein precipitation, cell debris pelleting, and routine micro-tube spin-downs across various tube formats.
Thermo Scientific™ S4 Series Centrifuges
Models included: S4T (Ventilated Benchtop) | S4TR (Refrigerated Benchtop) | S4FR (Refrigerated Floor-Standing)
The Thermo Scientific S4 Series centrifuges provide high-capacity, heavy-duty sample separation for high-throughput clinical diagnostic laboratories, cell culture facilities, and bioprocessing centers. Supporting swing-out capacities up to 4 x 1,000 mL (4 Liters) and speeds up to 25,830 x g, the S4 Series combines quiet operation with eco-friendly GreenCool refrigeration technology. Manufactured in a certified zero-waste facility in Germany, it delivers sustainable, high-capacity productivity while ensuring rigorous sample protection and temperature stability.
Technological Innovations & Core Capabilities
- Auto-Lock™ Rotor Exchange: Fast, push-button, tool-free rotor installation supporting up to 13 application-specific rotors for seamless workflow transitions.
- GreenCool™ Natural Refrigerant: Advanced R290 cooling system featuring a Global Warming Potential (GWP) of just 3, zero ozone depletion, and reduced energy consumption (S4TR / S4FR).
- High-Capacity Ergonomics: Accommodates up to 4 Liters of sample volume in both space-saving benchtop and floor-standing (S4FR) footprints designed to optimize bench space.
- ClickSeal™ Biocontainment Lids: Certified glove-friendly, one-handed aerosol-tight sealing system for hazardous biological samples and clinical materials.
- Dual Regulatory Certifications: Available in IVD-MD (EU IVDR Class A / FDA Listed Class 1) for regulated diagnostic centers and General Use configurations for research.
Intended Applications
- Clinical Diagnostics: High-volume processing of primary blood collection tubes and diagnostic samples under IVD compliance.
- Cell Culture & Bioprocessing: Large-volume harvesting, cell pelleting, and media separation in 15 mL, 50 mL, and 250 mL/500 mL/1,000 mL vessels.
- Genomics & Proteomics: High-speed separation for spin-column purification, multi-well microplates, and high-density cell lysates.
Thermo Scientific™ S2 Series Benchtop Centrifuges
Models included: S2T (Ventilated Benchtop) | S2TR (Refrigerated Benchtop)
The Thermo Scientific S2 Series centrifuges provide exceptional performance, efficiency, and versatility for mid-capacity sample processing in clinical diagnostics and research laboratories. Supporting swing-out capacities up to 4 x 400 mL and speeds up to 25,830 x g, the S2 Series combines an ultra-quiet design with eco-friendly GreenCool technology. Manufactured in a certified zero-waste facility in Germany, it delivers sustainable operations without compromising cooling speed or sample protection.
Technological Innovations & Core Capabilities
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Auto-Lock™ Rotor Exchange: Quick, push-button, tool-free rotor swapping supporting up to 15 application-specific rotors.
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GreenCool™ Natural Refrigerant: Next-generation R290 cooling system with a Global Warming Potential (GWP) of just 3, zero ozone depletion, and up to 15% energy savings compared to previous generations (S2TR).
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Ultra-Quiet & Ergonomic: Class-leading low noise operation (below 42 dB(A) for ventilated S2T models and below 52 dB(A) for refrigerated S2TR models) engineered to enhance laboratory working environments.
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ClickSeal™ Biocontainment Lids: Glove-friendly, aerosol-tight sealing system certified for safe handling of clinical or hazardous samples.
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Dual Regulatory Certifications: Available in IVD-MD (EU IVDR Class A / FDA Listed Class 1) for diagnostic applications and General Use configurations.
Intended Applications
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Clinical Diagnostics & Pathology: Medium-throughput processing of primary blood collection tubes and urine containers under strict IVD regulatory standards.
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Cell Culture & Sample Prep: Gentle pelleting and washing of cell suspensions in 15 mL and 50 mL conical tubes.
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Genomics & Proteomics: High-speed centrifugation for microplate purification, spin-column nucleic acid extraction, and protein work.
Thermo Scientific™ C Series Compact Centrifuges
Models included: C1T (Ventilated Benchtop) | C1TR (Refrigerated Benchtop) | C1FR (Refrigerated Floor-Standing)
The Thermo Scientific™ C1 Series centrifuges deliver high-capacity sample separation in an exceptionally compact footprint, designed specifically for clinical diagnostics and life science research laboratories where space, speed, and sample integrity are critical. Offering up to 4 x 145 mL swing-out capacity and speeds up to 30,279 x g, the C1 Series seamlessly bridges routine blood/urine processing with advanced cellular and molecular workflows, combining eco-friendly GreenCool™ technology with certified biocontainment protection.
Technological Innovations & Core Capabilities
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Auto-Lock™ Rotor Exchange: A tool-free, push-button rotor exchange mechanism that allows operators to switch between swinging-bucket and high-speed fixed-angle rotors in seconds, ensuring maximum versatility across multi-user environments.
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GreenCool™ Natural Refrigerant Technology (C1TR / C1FR): Powered by R290 natural hydrocarbon refrigerant, achieving a Global Warming Potential (GWP) of just 3. This system reduces power consumption by up to 15.7% compared to previous generations while eliminating harmful PFAS environmental byproducts.
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ClickSeal™ Biocontainment Lids: Certified glove-friendly, one-handed biocontainment sealing system that provides verified aerosol protection for hazardous or clinical samples.
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Dual Compliance & Certification: Available in both IVD-MD (EU IVDR Class A / FDA Listed Class 1) for regulated diagnostic laboratories and General Use configurations for academic and industrial R&D.
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Space-Optimized Ergonomics: Engineered to maximize bench space without compromising sample capacity, with an available floor-standing model (C1FR) for labs seeking to free up critical workspace entirely.
Intended Applications
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Clinical Diagnostics & Pathology: High-throughput processing of blood collection tubes (5/7 mL, 10/12 mL) and urine tubes for hematology, immunology, and clinical chemistry.
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Cell Culture & Sample Preparation: Low-speed, gentle pelleting of mammalian, mammalian cell lines, and primary cells in 15 mL and 50 mL conical tubes.
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Molecular Biology & Genomics: Nucleic acid cleanup, plasmid isolation, and protein precipitation, supporting both high-capacity conical tubes and optional spin-column MicroClick™ rotors.
SL4 Plus Centrifuge Series
The ST4/ST4R Plus series centrifuges come standard with an easy-to-use keypad and high contrast LCD display. This high-capacity and versatile unit offers consistent performance and is ideal for routine applications. Quickly and securely swap between 13 unique rotor options with the tool-less Auto-Lock rotor exchange. Available for purchase individually or in convenient application-based packages.
Cell Culture packages include the centrifuge, rotor, ClickSeal biocontainment lids and a set of four 15 mL and 50 mL conical tube adapters.
Blood Tube packages include the centrifuge, rotor, ClickSeal biocontainment lids and a set of four 5/7 mL and 9/10 mL blood tube adapters.
Optima XPN Preparative Ultracentrifuge
The Optima XPN is a high-performance floor-model preparative ultracentrifuge engineered for the isolation, fractionation, and purification of macromolecules, cellular organelles, and viral particles. Operating across three configurations—100,000 RPM, 90,000 RPM, and 80,000 RPM—the platform generates maximum centrifugal forces of up to 802,000 x g. This system is heavily utilized across academic core facilities, biopharmaceutical process development (R&D), industrial quality control (QC) laboratories, and clinical virology centers for high-resolution macromolecular separations. Designed for precision preparative workflows, the system utilizes a highly efficient thermoelectric refrigeration system (free of CFCs and ozone-depleting chemicals) that maintains strict temperature control within +/- 0.5 degrees C of the set temperature. Speed control is regulated within +/- 2 RPM of the set speed at velocities above 1,000 RPM. The drive system features quiet-drive technology, maintaining operational sound levels below 51 dBA to ensure a quiet laboratory environment.
Core Technologies & Operational Features
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Advanced Software & Simulation: Equipped with proprietary Optima eXpert software, providing on-board calculations, simulations, and reference tools. This allows operators to mathematically model sedimentation profiles and optimize protocols prior to initiating physical runs.
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Rotor Versatility & Tracking: Compatible with existing Beckman Coulter preparative rotors, including Fixed-Angle, Swinging-Bucket, Vertical-Tube, and Near-Vertical configurations. The system logs and tracks detailed rotor usage history and life cycles by individual serial numbers to ensure instrument safety.
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Specialized Operational Modes: Features step-by-step dedicated screens for Zonal and Continuous Flow (CF) operations, standardizing the scale-up and processing of large-volume separations.
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Data Integrity & Traceability: Supports multi-user environments with 50 unique user profiles and passwords under three distinct user access levels. The software generates exportable run logs and supports electronic signatures to maintain a strict chain of custody and GxP compliance.
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Power & Run Stability: Engineered with enhanced power tolerance, automatically adjusting transformer taps to handle voltage fluctuations between 180 VAC and 264 VAC. In the event of a power interruption, the system tracks and records parameter data to verify if the run remained within acceptable boundaries.
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Energy Management: Utilizes a regenerative braking system that reclaims deceleration energy and returns it to the local electrical circuit. During idle states, power consumption is minimized to the equivalent of a 60-watt light bulb.
Primary Preparative Applications
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Preparative Density Gradient Separations: Execution of Rate-Zonal (separation by size/shape) and Isopycnic (separation by buoyant density) centrifugation using gradient media such as Cesium Chloride (CsCl), Sucrose, or Iodixanol.
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Viral Vector Purification: Concentration, isolation, and downstream cleaning of Adeno-Associated Virus (AAV), Lentivirus, Adenovirus, and enveloped viral particles for gene therapy and vaccine development.
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Extracellular Vesicle & Exosome Fractionation: Differential pelleting and subsequent gradient purification of exosome subpopulations from cell culture supernatants or physiological fluids.
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Subcellular Component Isolation: Separation and isolation of intact organelles (mitochondria, nuclei, microsomes, lysosomes) and plasma membrane fractions.
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Macromolecular & Nucleic Acid Fractionation: Isolation of ribosomal subunits, multi-protein complexes, plasmid DNA, and chromosomal DNA fractions.
Looking for the complete solution? Discover how OptiMATE, Optima XPN, and OptiXTRACT integrate seamlessly into an end-to-end separation workflow. Visit our Knowledge Center Hub.
Optima AUC – Analytical Ultracentrifuge
AUC enables researchers two complementary views of solution behavior. Sedimentation velocity provides first-principle, hydrodynamic information about the size and shape of molecules. Sedimentation equilibrium provides the same type of information about the solution molar masses, stoichiometries, association constants and solution nonideality. Scientist can investigate nearly any type of molecule or particle over a wide range of concentrations and in a diverse variety of solvents and characterize samples in their native state under biologically relevant solution conditions.
Extracellular Vesicles
AUC can be an effective method to determine
EV composition and concentration.
Nanoparticle Analysis
AUC allows resolution of up to 1nm. Provides population statistics and determines the shape
of the particle.
Carbon Nanotubes
AUC can distinguish between more than 300 different species of carbon nanotubes, their length, purity and integrity.
Drug Discovery
Analytical ultracentrifugation allows characterization of:
•Conjugation efficiency of Antibody -Drug conjugates
•Toxicology lot evaluation
•API and drug formulation stability and lot release
•Formulation stress testing
Stoichiometry
AUC can distinguish between hydrodynamically unresolved materials. Elucidating the relative amounts of species in a co-sedimenting complex. In conjunction with additional hydrodynamic information- True Stoichiometry can be obtained.
Aggregation Analysis
AUC allows non disruptive study of protein interactions in almost any buffer.
•Determination of “s” and “D”. Size distributions are not affected
•Differentiates reversible and irreversible aggregation
•Ternary interactions. Simultaneous determination of: Kd, Koff, concentration,
size and stoichiometry
Structural Analysis of Proteins
AUC is useful in determining such parameters as Polydispersity and Aggregation.
Allows rigorous quantitative determination of hydrodynamic and thermodynamic properties.
Complementary to structural biology.
AAV
AUC allows:
•Determine viral assembly state or homogeneity (empty, full or oligomer), Empirically quantify aggregation
•Determine sub- particle contamination
•Mass quantification to accurately measure genetic payload
Sedimentation Analysis
AUC allows the determination of Size, Anisotropy and Density. Dynamics, Composition and Conformation.
SL1 Plus Centrifuge Series
The SL1/SL1R Plus series centrifuges come standard with an easy-to-use keypad and high contrast LCD display. Quickly and securely swap between 14 unique rotor options with the tool-less Auto-Lock rotor exchange. This compact centrifuge has a capacity up to 1.6L and can spin up to 76 x 5/7 mL blood tubes and 16 x 50mL conical tubes with biocontainment and is ideal for routine applications.
Auto-Lock™ III Rotor System:
- Secure locking system allows easy push-button installation and exchange of rotors.
- System saves time when switching between applications.
- Easy access to rotor chamber offers quick cleaning, a healthier working environment and longer unit life.
ClickSeal™ Bucket Sealing System:
- Biocontainment solution seals with a snap; eliminates screw caps and complicated clips.
- System has glove-friendly, one-handed open/close capability.
- System is certified by CAMR™ in Porton Down, UK.
SMARTSpin™ Technology:
- Advanced rotor management system maximizes acceleration, braking and residual load imbalance for each rotor and bucket option:
- Technology optimizes safety and improves separations.
MicroCL 17R Microcentrifuge
Ideal for everyday laboratory use, Thermo Scientific MicroCL 17R microcentrifuges provide outstanding processing power, unique safety features and a broad array of microcentrifuge rotors and accessories for microcentrifuge tube processing, with refrigeration available.
Support your micro-volume separation needs with:
- Performance up to 17,000xg with fast acceleration and deceleration.
- Refrigerated versions offer cooling from room temperature to set temperature in as little as 9 minutes.
- Choose from 7 optional microcentrifuge rotors to find the ideal fit for your application:
- Outstanding corrosion resistance with lightweight engineered polymer rotors.
- Standard rotor runs 24 microcentrifuge tubes in a single row, from 1.5 to 2.0 mL tubes to mini-preps and spin columns.
- Ergonomic one-click rotor opening and closing, as well as transparent design for added safety and convenience with Thermo Scientific ClickSeal biocontainment lids.
- Eliminate the need for adapters with unique dual row rotor.
- Simplify operation with intuitive controls, easy-to-read displays and fast one-click centrifuge lid closure.
- Sleek, lightweight, space-saving design.
- Durable and easy to clean and maintain.
- Quiet performance promotes a safe, stress-free environment.
- Conforms to the latest clinical and safety standards, including 98/79/EC In Vitro Diagnostic Directive.
