PRODUCTS
Cell Factory Systems
With the same growth kinetics as laboratory-scale cell culture products, Nunc Cell Factory systems are a proven solution for large-scale production of cells, vaccines, and therapeutic proteins. Our hands-on expertise will help you accelerate productivity and ease the burden of regulatory compliance. This quality production cell culture platform reflects the rigorous standards that have made us the world’s leading provider of cell culture products.
Impurity and Contaminant testing
Quickly evaluate and monitor your biopharmaceutical production process
Monitoring the quality, safety, and potency of your pharmaceutical product during manufacturing is important—and testing accuracy and time-to-results are critical. Our robust portfolio of Applied Biosystems SEQ analytical testing solutions employs rapid, highly sensitive molecular methods to efficiently detect impurities, identify contaminants, and quantify titer. Delivering same-day results, often in less than 5 hours, our analytical solutions can help meet regulatory compliance for characterization and lot release testing.
Rebel-Amino Acids Analyzer
Under 10 minute – Monitor amino acids and media composition over the course of the cell culture process. Identify depleted nutrients and refine supplementation strategies on the fly. Correlate media composition to product yield and quality.
The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis. Combining award winning design with 908 Devices proven capillary electrophoresis and high-pressure mass spectrometry technologies, the REBEL provides process development scientists access to critical data at-line, any time.
MAVERICK
Real-time, in-line bioprocess analysis and control, right out of the box. Measurements of multiple critical parameters across media, across processes, across mammalian cell lines, across scales.
MAVERICK is powered by Raman spectroscopy and a purpose-built de novo model. The de novo model is explicitly built on media chemistries and device physics, not on empirical data. It automatically interprets the spectra and quantifies process parameters enabling simultaneous measurements of glucose, lactate, and total biomass. This is achieved without the costs, complexities, and risks associated with conventional Process Analytical Technology (PAT) methods. There is no need to grapple with complex empirical models, reagents, or unreliable auto-sampling systems to implement in-line bioprocess analysis.
Multiplex Flex Up to six measurement modules can be connected to a single MAVERICK hub. Independently monitor process conditions and control feeds in multiple bioreactors, in real-time, simultaneously. Save valuable bench space and increase efficiency.
TRACE C2
On-Line Fermentation Analyzer – Monitor key nutrients and metabolites on-line and control feed automatically. TRACE C2 Control lets you maintain optimal fermentation process conditions for laboratory or industrial cultivations of microorganisms.
TRACE C2 offers online monitoring of methanol or ethanol and control of substrate feeding. There’s no direct sampling, so there’s no volume loss. Only real-time insights and real-time control for optimal productivity of your fermentation process.
With TRACE C2 connected to your fermenter, you can quickly get up and running with 30 automated measurements per hour. No pipettes. No contamination risk. No babysitting your fermenters during off-hours. Diffusion probe is installed in a fermenter and connects to TRACE C2 measurement cell with a pre-configured tubing set. Only methanol or ethanol molecules are small enough to diffuse through the semi-permeable membrane into the buffer fluid, so there is no loss of bioreactor volume and no increased risk of process contamination.
BioProfile® FLEX2
Automated Cell Culture Analyzer with Maintenance-Free Chemistry Sensors
BioProfile FLEX2 combines Nova’s groundbreaking MicroSensor™ Card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume. The full 16 cell culture test menu includes: Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca++, pH, PCO2, PO2, total cell density, viable cell density, viability, cell diameter, and osmolality.
Compared to the previous generation BioProfile FLEX there is no maintenance for any of the 11 chemistry and gas sensors, sample volume for the full test menu is reduced by 75% to 275 microliters, and testing time is reduced to just 4.5 minutes. Automated sampling from 96-well plates, syringes, or a 24-position external “load-and-go” sample tray provides maximum workflow flexibility and efficiency for cell culture monitoring.
MiniFlex Benchtop Powder X-ray Diffraction (XRD)
Qualitative and quantitative phase analysis of poly-crystalline materials
The MiniFlex benchtop X-ray diffractometer is a multipurpose powder diffraction analytical instrument that can determine: crystalline phase identification (phase ID) and quantification, percent (%) crystallinity, crystallite size and strain, lattice parameter refinement, Rietveld refinement, and molecular structure. It is widely used in research, especially in material science and chemistry, as well as in industry for research and quality control. It is the newest addition to the MiniFlex series of benchtop X-ray diffraction analyzers from Rigaku, which began with the introduction of the original MiniFlex XRD system decades ago.
SmartLab Automated Multipurpose X‑ray Diffractometer (XRD) With Guidance Software
Powder diffraction, thin film metrology, SAXS, in-plane scattering, operando measurements
Rigaku SmartLab is the newest and most novel high-resolution X-ray diffractometer (XRD) available today. Perhaps its most novel feature is the new SmartLab Studio II software, which provides the user with an intelligent User Guidance expert system functionality that guides the operator through the intricacies of each experiment. It is like having an expert standing by your side.
This new X-ray diffraction system features the PhotonMax high-flux 9 kW rotating anode X-ray source coupled with a HyPix-3000 high-energy-resolution 2D multidimensional semiconductor detector that supports 0D, 1D and 2D measurement modes, allowing all applications to be handled with a single detector, eliminating the inconvenience of preparing and switching individual detectors for different applications. The HyPix-3000 detector can be used to obtain 2D powder diffraction patterns, which can be processed to deliver superior qualitative analysis by using all the 2D pattern information. The system incorporates a high-resolution θ/θ closed loop goniometer drive system with an available in-plane diffraction arm. The system’s new Cross-Beam-Optics (CBO) family feature fully automated switchable reflection and transmission optics (CBO-Auto).
SmartLab SE Multipurpose X-ray Diffraction System with Built-In Intelligent Guidance
Powder diffraction, thin film diffraction, SAXS, pole figure, residual stress and non-ambient experiments
The SmartLab SE is a highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance. It offers continued refinement of the original ease of use features that enabled the original SmartLab to receive the R&D 100 Award in 2006: automatic alignment, component recognition, cross beam optics and advanced photon counting hybrid pixel array detectors (HPAD).
SmartLab Studio II incorporates a built-in Guidance expert system that suggests the optimal hardware configuration and settings for specific application measurements. The software will determine which optics are most appropriate for a given application, determine the instrument settings and execute the measurement, delivering a completely automated measurement sequence. Since the SmartLab SE has built-in component recognition, Guidance will not only tell you how you should configure the SmartLab SE for a given measurement, it will also warn you if you have not configured it properly. Expert advice coupled with hardware that will confirm the correct configuration is the foundation of the SmartLab SE platform.
XtaLAB Synergy-ED Fully Integrated Electron Diffractometer
A system any X-ray crystallographer will find intuitive to operate
XtaLAB Synergy-ED is a new and fully integrated electron diffractometer, creating a seamless workflow from data collection to structure determination of three-dimensional molecular structures. The key feature of this product is that it provides researchers an integrated platform enabling easy access to electron crystallography. The XtaLAB Synergy-ED is a system any X-ray crystallographer will find intuitive to operate without having to become an expert in electron microscopy.
The XtaLAB Synergy-ED is the result of an innovative collaboration between Rigaku and JEOL, to synergistically combine Rigaku’s core technologies: Rigaku’s high-speed, high-sensitivity photon-counting detector (HyPix-ED) and state-of-the-art instrument control and single crystal analysis software platform (CrysAlisPro for ED), and JEOL’s long-term expertise and market leadership in designing and producing transmission electron microscopes.
XtaLAB Synergy-R High-Flux Rotating Anode X-ray Diffractometer
A powerful and fast system for single crystal X-ray diffraction analysis
The XtaLAB Synergy-R was designed to address the increasing need to investigate smaller and smaller samples in crystallographic research. Tightly integrating a PhotonJet-R microfocus rotating anode X-ray source with a high-speed kappa goniometer and a solid-state pixel array HPC detector creates a single crystal diffractometer that produces up to 10 times the flux as compared to a PhotonJet-S microfocus sealed tube source. The increase in flux allows you to look at much smaller crystals than before and as a side benefit it provides increased data collection speed for normal sized crystals.
The system can be equipped with your choice of HPC hybrid photon counting detectors, the HyPix-6000HE or the curved, large theta coverage detectors, HyPix-Arc 100° or HyPix-Arc 150°. For crystallographers who wish to have a powerful, well-integrated diffractometer and only need to use one port of the rotating anode, the XtaLAB Synergy-R provides the perfect combination of high-flux performance with a low-noise HPC X-ray detector.
XtaLAB Synergy-S Single Or Dual Microfocus X‑ray Diffractometer
A fast and agile single crystal X‑ray diffractometer for small molecule 3D structure analysis
With your success utmost in our minds, we have developed the XtaLAB Synergy-S X-ray diffractometer for single crystal X-ray diffraction. Using a combination of leading-edge components and user-inspired software tied together through a highly parallelized architecture, the XtaLAB Synergy-S produces fast, accurate data in an intelligent fashion.
The system is based around the PhotonJet-S series of microfocus X-ray sources that optionally incorporate continuously variable divergence slits. These third-generation sources have been designed to maximize X-ray photons at the sample by using a combination of new optics, new longer-life tubes and an improved alignment system. PhotonJet-S sources are available in Cu, Mo or Ag wavelengths in either a single or dual source configuration. The XtaLAB Synergy-S single crystal X-ray diffractometer comes with a kappa goniometer that incorporates fast motor speeds and a unique telescopic two-theta arm to provide total flexibility for your diffraction experiment. The system is also equipped with your choice of HPC hybrid photon counting detectors, the HyPix-6000HE or the large theta coverage detectors: HyPix-Arc 100° or HyPix-Arc 150°.
