Bioproduction
Rhenium’s Bioproduction department specializes in process development, biologic manufacturing, and quality control. We offer comprehensive solutions for both Upstream and Downstream processes, helping you streamline your workflow. Our team also provides custom solutions, technical support, and application guidance to meet your specific needs. With Rhenium, you can leverage advanced bioproduction technologies to enhance your work in the field.
SBP Research Kit Capsules
Encapsulate your own microbial culture in a Ready to Use bioreactor for research applications
Ready to use bioreactors, effectively support microorganism growth and proliferation in aquatic mediums and water saturated ground.
The highly affordable SBP Research Kit is changing how experiments are done in research laboratories.
SBP Research Kit capsules are shipped sterile & can be populated with various types of microorganisms including bacteria, archaea, yeast and other types of fungi. Population is completed within minutes.
Bioreactor Systems by Thermo Fisher Scientific
Discover the advantages of a comprehensive bioreactor portfolio, enabling scalability from research to cGMP manufacturing
Biopharmaceutical applications requires a solution to support robust cell growth. Thermo Scientific offers a range of bioreactors perfectly suited for mammalian cell culture and microbial fermentation applications that span process development, clinical trials, and large-scale commercial biomanufacturing. The bioreactor portfolio offers options from 1 L glass bioreactors to 2,000 L single-use bioreactors. Our system solutions allow you to choose the ideal match for your process parameters. Bioreactor Systems:
Glass Bioreactors
Open Architecture Single-Use Bioreactors
Rocker Bioreactor
DynaDrive Single-Use Bioreactor
Bioreactors systems by Infors
Bench-top and pilot bioreactors offer practical solutions for mammalian cells, bacteria and yeast cultivations. The bench-top bioreactor offers features beyond those of other devices of its class.
Bench-Top Bioreactors
Minifors 2
A compact and easy-to-use bioreactor with a full range of application possibilities. It is a complete package that enables both, beginners and experienced users to easily perform applications.
Multifors 2
With Multifors 2 you can work with up to six bioprocesses in parallel. Thanks to a selection of preconfigured packages and a variety of connection possibilities and options, you will be ideally equipped for optimizing sophisticated bioprocesses on a small scale.
Labfors 5
The Labfors 5 is suitable for microorganisms, phototrophic organisms as well as solid subtrates and enzymatic bioprocesses. There are almost no limits to its uses.
Pilot Bioreactors
Techfors-S
The Techfors-S contains exactly the same components as Infors bench bioreactors. This ranges from the pumps via the gassing line to the touch screen controller and the associated software. Both beginners as well as process experts will be able to manage easily. Minimum working volume of 3 liters. The double jacket of the Techfors-S vessels guarantees optimum temperature control even at low starting volumes – essential for modern fed-batch fermentations. Thanks to its compact design and mobile stand, the Techfors-S can be used anywhere.
Techfors
There are practically no limits on flexibility with regard to design and operation, since each pilot bioreactor model is built individually according to your needs. You specify the requirements – we implement them after performing a thorough feasibility study.
Cell culture media
Since 1962, GIBCO have been empowering progress in bioprocessing around the world. Our pioneering end-to-end products, process development and customization services can help maximize productivity while reducing costs and time to market. Our portfolio include:
• Culture solution for Biosimilars, Vaccine production ,Cell and Gene therapy.
• High-performing CHO media designed to optimize your workflow, including media that is chemically defined, animal origin–free, serum-free, and more.
• Manufacture customized media or your formulation for production, provide non-GMP media prototyping, and create custom packaging, supporting your entire media manufacturing journey.
• Range of feeds and supplements that can enhance your cell culture up to a 2- to 5-fold increase over batch culture.
Gibco Peptones
Enhance your cell culture performance
We offer an extensive portfolio of nutritionally diverse animal origin (AO) and animal origin—free (AOF) peptones to supplement a variety of cell culture media.
Alternative to serum – Offers essential nutrients shown to increase performance and production in a variety of vaccine applications.
Protective effects – Fortifies cell culture medium to improve cultivation, productivity, and anti-apoptosis properties during scale-up.
Performance enhancer – Reduces time to market with high-performance products that meet stringent quality standards and rigorous raw sourcing policies.
XCell® ATF System
Simplify and intensify upstream bioprocessing. The XCell® ATF System, in single-use or stainless steel format, delivers superior cell retention. High impact upstream applications include N-1 perfusion, high productivity harvest, long-term perfusion and seed train intensification. XCell® ATF Systems simplify and fast-track upstream intensification by providing an integrated solution consisting of an XCell® ATF Device, XCell® ATF Controller, software, tubing, pressure sensors and accessories. The family of Systems supports diverse applications across development from 1L to 5000 L.
KrosFlo® KR2i TFF System
Single-use fully integrated benchtop TFF system for use in lab scale process development ranging from 2mL – 15L. Compatible with hollow fiber or flat sheet filters, this system offers many user-defined set-point controls so you can run complex applications in fully-automated modes. The fully integrated KrosFlo KR2i TFF System features a digital peristaltic pump, graphical LCD display, digital pressure monitor, KR2i Pump head, automatic backpressure valve, filter module stand, and KF Comm real-time data collection software. Highly configurable and versatile, the KrosFlo KR2i utilizes a number user-defined set-points to run complex application processes with numerous built-in safety alarms and stops. The system can run up to two stackable pump heads for higher flow rates.
Spectrum® Hollow Fiber Modules
Spectrum® Hollow Fiber Filter Modules: Ideal for ultrafiltration, diafiltration and microfiltration, single-use hollow fiber filters for tangential flow filtration are packed in housings engineered to handle high pressures, with a choice of fiber chemistries and sizes from process development to manufacturing. Spectrum® Hollow Fiber Membranes: Fully encapsulated in single-use modules, the membranes used in the hollow fiber filter modules from Repligen are constructed using four chemistries that are anisotropic in structure to deliver high flux rates, excellent separation, and low protein binding for higher product yields.
Bioprocess Resins
When you need high performance and high throughput on a large scale, POROS bulk chromatography resins enable outstanding performance for process-scale bioseparations. Utilized in multiple processes, these breakthrough resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS 50 µm resins demonstrate exceptionally high resolution, dynamic binding capacity, and capture efficiency over a range of flow rates and are primarily used in polish applications.
CaptureSelect affinity resins offer excellent selectivity resulting in higher yields and improved purity in the initial capture step. We have developed numerous products for large-scale purification of various biologics such as antibodies and antibody fragments, fusion proteins, hormones, and viruses.
TOYOPEARL and TSKgel Process Media (TOSOH)
TOSOH BIOSCIENCE: TSKgel and TOYOPEARL resins are specifically designed for use in biopharmaceutical production. Based on a rigid polymer structure, they show excellent physical strength and flow characteristics, resulting in faster process throughput. Optimized pore diameters and narrow particle size distribution allow rapid kinetics and exceptional resolution.
TOYOPEARL and TSKgel resins are applied from capture, through intermediate purification, to polishing. Target molecules range from peptides and proteins to oligonucleotides and plasmids.
Single Use Mixers
We offer two main mixing platforms from Thermo Fisher Scientific that address the needs of proper preparation of media, buffers, and other process liquids. These are designed for the liquid/liquid and powder/liquid mixing of media, buffers, intermediates, final products, process liquids, and suspensions—with all the benefits of single-use technology. Mixing systems are based on two different yet efficient mixing systems—a bottom-driven impulse mixing system, and a top-down driven mixing system based on traditional stainless steel mixing principles.
BioLector XT Microbioreactor
The high-throughput microbioreactor enables real-time evaluation of biomass, fluorescence, pH, dissolved oxygen in the liquid phase (DO), and other key cultivation parameters for aerobes and anaerobes.
Building on trusted BioLector Pro technology, the BioLector XT microbioreactor is based on a standard ANSI/SLAS (SBS) microtiter plate (MTP) format, and operates with online, pre-calibrated optical sensors. Disposable 48 well MTPs enable online measurement of cultivation parameters, while patented microfluidic technology supports simultaneous pH control and feeding. The optional microfluidic module eliminates manual liquid handling—no tubing or pipetting required, as everything is part of the gamma-radiated ready-to-use plate.
Innovative New Gassing Head
- Enables fed-batch experiments under anaerobic conditions
- Gassing with O2 within a range of 1% – 100% and with CO2 within 1% – 12 %
- Reduces gas consumption to a few mL/minute
- Optional humidification of gases reduces evaporation
Optional Microfluidic Module
- Unleashes full potential of the BioLector XT
- Complements online monitoring function with well-specific pH regulation/feeding
- Enables use of 2 reservoir wells per 4 cultivation wells
- Microvalves allot liquids at nanoliter-scale
“Plug-and-play” Plate Design
- Real-time kinetics out of 48/32 parallel cultivations
- Customizable feeding strategies (batch, fed-batch, bolus, continuous)*
- Control of pH on-the-plate with pre-calibrated optical sensors*
- Small working volume (800 – 2400 μL)
Intelligent BioLection Software
- Intuitive user interface supports multi-user environments
- Free programming of all control parameters
- Open system enables live data downloads
- Fast processor ensures rapid download of experiment data
