CryoArc™ Tera & Tera for Cassettes Automated Cryogenic Storage System

The CryoArc™ Tera platform represents a high-capacity, fully automated liquid nitrogen vapor-phase storage solution built to consolidate large sample collections down to a uniform -190°C baseline environment. Optimized for enterprise-scale operations, the system integrates advanced robotics with comprehensive inventory control to eliminate manual rack lifting and safeguard biological assets from accidental thermal exposures above the water glass transition boundary (Tg -135°C).

The platform is deployable across two core configurations: the standard CryoArc™ Tera layout optimized for standard cryobox racking, and the specialized CryoArc™ Tera for Cassettes framework. The specialized Cassette configuration integrates dedicated mechanical sub-structures designed specifically for advanced cell and gene therapy (CGT) manufacturing lines and high-throughput cleanrooms, processing exactly one clinical lot at a time to shield adjacent materials from ambient exposure.

Key Advantages

• Thermal Exposure Mitigation: Automated single-container retrieval mechanisms isolate transactions, preventing non-targeted innocent samples from undergoing transient warming events.

• Footprint Optimization: Maximizes vertical and physical facility space to enable ultra-high-density storage within a single consolidated footprint.

• Rigorous Integrity Control: Standardizes handling operations, eliminates physical operator exposure to cryogenic hazards, and enforces total chain-of-custody data verification.

Ideal Applications

• National biorepositories, global pharmaceutical research hubs, and large-scale genetic banks

• Commercial Cell & Gene Therapy (CGT) cleanrooms and advanced therapy manufacturing centers

• High-throughput clinical trial repositories and industrial master cell banks (MCB)

Robotic Automation & Labware Handling

• Insulating Tower Architecture: Internal engineering incorporates an insulated vertical handling tower that acts as a thermal barrier, maintaining internal sample temperatures even during vertical movement cycles.

• Single-Cassette Processing Core: The specialized Tera for Cassettes mechanics handle exactly one container element independently, ensuring adjacent packages remain undisturbed inside the baseline cryogenic environment during inventory management routines.

• High-Speed Execution Turnaround: Robotic container retrieval execution is completed in less than 60 seconds to secure continuous cold chain infrastructure continuity.

Integrated Software & Regulatory Compliance

• Integrated CryoArc Software Platform: Tracks individual sample location, sample movement parameters, and user access metrics across the sample’s operational lifetime.

• Real-Time Telemetry Logging: Captures critical environmental data, including internal temperature uniformity, unexpected system events, operational alarms, liquid nitrogen levels, and nominal LN2 usage rates.

• Enterprise LIMS Connectivity: Employs an optional WebAPI module to seamlessly integrate tracking telemetry with homegrown or enterprise Laboratory Information Management Systems (LIMS).

• Audit Trail Generation: Fully supports adherence to FDA 21 CFR Part 11 compliance standards. All sample history, user validation logs, and performance parameters can be downloaded in a standardized format for immediate inclusion in official audit reports.

• Electronic Quarantine Controls: Software-enabled electronic quarantine functionality permits administrators to flag, isolate, and restrict access to specific containers within the automated framework.

Infrastructure Redundancy & Disaster Protection

• Extended Hold Time Stability: Provides up to 21 days (Standard Tera configuration) or up to 23 days (Specialized Cassette layout) of continuous static temperature stability to protect stored biological assets during total facility electrical outages or liquid nitrogen supply interruptions.

• Onboard Integrated UPS: Features an onboard uninterruptible power supply (UPS) to sustain the software storage environment, internal telemetry data collection, and system monitoring parameters during sudden power disruptions.

Technical Specifications

Storage Capacity (Standard Tera Layout): Accommodates 630 x 2” standard laboratory cryoboxes (or equivalent), supporting mix-and-match configurations of cryovials and cassettes

Storage Capacity (Specialized Cassette Layout): Configured to store up to 990 large 250ml scale cryo cassettes

Operating Temperature Baseline: -190°C (Liquid Nitrogen Vapor Phase environment)

Emergency Static Holding Time: 21 to 23 days to maintain a baseline of -135°C (configuration dependent)

System Physical Dimensions (H x W x D): 125.10″ x 60.00″ x 79.00″ (3,179 mm x 1,524 mm x 2,007 mm)

System Structural Weight (Standard Tera): 2,237 lbs (1,016 kg) Empty / 3,582 lbs (1,627 kg) Full Estimated Baseline

System Structural Weight (Cassette Layout): 2,231 lbs (1,054 kg) Empty / 3,441 lbs (1,563 kg) Full Estimated Baseline

Maximum Structural Floor Load (Standard Tera): 109 lbs/ft² (533 kg/m²)

Maximum Structural Floor Load (Cassette Layout): 105 lbs/ft² (512 kg/m²)

Electrical Input Parameters: 110V / 220V, Single Phase

System Power Consumption Metrics: 100 Watts (Idle) / 220 Watts (Maximum output)

LN2 Supply Line Interface: 1/2″ NPT Male Fitting to existing LN2 Supply Line

LN2 Operational Supply Pressure: 22-35 psig (1.52 – 2.41 bar) under open valve workflow

LN2 Evaporation Rate (Nominal): Approximately 13.6 Liters per day

Operating Environment Limits: Temperature: 18°C – 27°C (65°F – 80°F) | Humidity: Maximum 50% rH (non-condensing)

Regulatory & Compliance Index: CE Mark Directives, China RoHS, Conflict Materials, EU REACH, EU RoHS